For example, we found that levels of ADAR, XRCC6 and SBDS were reduced in 5 of 7 Alzheimer’s disease samples and levels of DDX5, U2AF2, ILF3 were reduced in 4 of 7 Alzheimer’s disease NPC vasculature samples by greater than 50%. The gene discussed is XRCC6; the disease is early-onset autosomal dominant Alzheimer disease.