For example, we found that levels of ADAR, XRCC6 and SBDS were reduced in 5 of 7 Alzheimer’s disease samples and levels of DDX5, U2AF2, ILF3 were reduced in 4 of 7 Alzheimer’s disease NPC vasculature samples by greater than 50%. This evidence concerns the gene U2AF2 and early-onset autosomal dominant Alzheimer disease.