We found that both ISGs and NF-κB regulated genes were over-expressed in Alzheimer’s disease total HPC and Alzheimer’s disease HPC vasculature compared to NCI HPC and NCI HPC vasculature, respectively, thus providing a correlate to the decreased levels of A-to-I editing observed in Alzheimer’s disease (Fig. 7). Here, NFKB1 is linked to early-onset autosomal dominant Alzheimer disease.