ADAR and early-onset autosomal dominant Alzheimer disease: Ro60 and TDP-43 are two examples.52,53 Loss of Ro60 expression or function has also been implicated in changes in A-to-I editing in multiple sclerosis.54 In addition, RBPs, such as DROSHA directly interact with ADAR to affect A-to-I editing.47 By examining our RNA-seq expression data for levels of different RBPs, we do not find uniform loss or gain of mRNAs that encode ADAR1, ADAR2 or other RBPs that either positively or negatively impact A-to-I editing in Alzheimer’s disease HPC or CTX vasculature compared to NCI HPC or CTX vasculature.