We compared expression levels of ADAR, ADARB1, and these other RBP encoding genes in NCI and Alzheimer’s disease cohorts in both HPC vasculature where we observe substantial loss of A-to-I editing in the Alzheimer’s disease cohort and CTX vasculature where we do not observe substantial loss of A-to-I editing in the Alzheimer’s disease cohort. Here, ADAR is linked to early-onset autosomal dominant Alzheimer disease.