Moreover, caution must be taken when substituting probiotics such as Bifidobacterium in AP, as Pushalkar et al., suggested that microbiota reconstitution with B. pseudologum accelerated oncogenesis in Abx-treated KPC mice, which express mutant intra-pancreatic Kras and p53.30 Further, considering the cell surface lactic acid receptor GPR81 is crucial to the survival of cancer cells, it is necessary to assess the appropriate, effective dose of lactate to be used, which is usually administrated in the form of lactated Ringer’s solution.23 This evidence concerns the gene TP53 and cancer.