In contrast, a single session of HFES attenuates HMGB1 release in the paw induced light stimulation in Vglut2-Cre/ChR2-eYFP mice (Fig. 3A; HMGB1: yellow light = 17.3 ± 1.2 ng/mg total protein, blue light = 29.8 ± 3.0, blue light + HF stimulation = 17.1 ± 3.1* ng/mg protein, N = 9-12 mice per group, *P < 0.05). The gene discussed is HMGB1; the disease is hydrops fetalis.