GLUL and Hepatic fibrosis: We provided evidence that ADSC-EXO possessed the anti-fibrotic potential in hepatic fibrosis, including restoring hepatic functions, promoting liver tissue repairing, reducing ECM deposition, down-regulating these key profibrogenic genes, etc. Importantly, we elucidated that ADSC-EXO treatment could suppress HSCs activation and remodel hepatocellular glutamine synthetase-mediated glutamine and ammonia metabolism, which played a vital role in improving liver microenvironment.