Considering the remarkable expression changes of these 13 mRNAs (SNRPG, RPS27A, COX7A2, ATP5PO, LSM3, COX7C, PFDN5, HINT1, PSMA6, RPS3A, RPL31, RPL35A and RPS20) in male and female patients with AD separately, they may play a role in AD pathogenesis. This evidence concerns the gene HINT1 and Alzheimer disease.