To explore whether the therapeutic effect of CDCs-exosomes can be improved by pan-cardiomyocyte targeting, the HHP was successfully displayed on the surface of exosomes derived from human CDCs, and the resulting exosomes were characterized, their targeting capability was confirmed, and their therapeutic effects to myocardial hypertrophy were evaluated in vitro in an Ang II-induced neonatal rat cardiomyocytes (NRCMs) hypertrophy cell model and in vivo in the TAC mouse model. This evidence concerns the gene AGT and cardiac hypertrophy.