Using univariate Cox regression analysis, 186 CAF-related DEGs were observably correlated with the BCRFS of prostate cancer patients, 16 of which were selected to construct a prognostic CAF signature for predicting BCRFS, such as ACPP, THBS2, and KCTD14. ACPP (prostate acid phosphate) is a secreted glycoprotein enzyme that is produced by in epithelial cells of the prostate gland in humans. This evidence concerns the gene KCTD14 and Familial prostate cancer.