HOPX and Familial prostate cancer: Furthermore, we also identified 142 CAF-related DEGs that were prominently correlated with the MFS of prostate cancer patients, 16 of which were selected to construct a prognostic CAF signature for predicting MFS, such as HOPX, TMEM132A, and ZNF467. HOPX (homeodomain only protein X) is identified as a metastasis-associated gene, which downregulation can control metastatic behavior in sarcoma cells [39].