TIMP1 and Ascending tubular aorta aneurysm: A previous study published by Pasha et al. showed that increased flow-based and structural descriptors of ascending aortic aneurysms were related to high levels of circulating biomarkers including matrix metalloproteinases (MMP), tissue inhibitors of metalloproteinase (TIMP), and exosomal level of miRNA in those with ascending aortic dilatation [17].