Post hoc analysis test revealed that the levels of hyperphosphorylated Tau protein were significantly increased in the ADC group mice compared to the WTC group mice (ADC vs. WTC, P < 0.01), mainly due to the abnormal accumulation of p-Tau proteins at Thr181 and Ser202 sites in the hippocampal region under AD pathology. This evidence concerns the gene MAPT and Alzheimer disease.