MAPK1 and colorectal carcinoma: Several studies have reported on the lncRNA–miRNA–mRNA signaling in CRC and demonstrated that PVT1 promotes CRC cell proliferation, migration, and invasion by upregulating COX2, FJX1, and MAPK1 via the modulation of miR-146a, miR-106b-5p, and miR-761 (Fig. 4I−K) [132–134], respectively.