Subsequently, several studies have shown that PVT1 promotes the invasion, migration, and proliferation of HCC cells by upregulating YAP1, HIG2, INCENP, and ATG3 by modulating miR-186-5p, miR-150, miR-424-5p, and miR-365 (Fig. 3B−E) [98–101], respectively. The gene discussed is PVT1; the disease is hepatocellular carcinoma.