Specifically, PVT1 reportedly promotes glioma cell proliferation, invasion, metastasis, and EMT by upregulating GREM1, PTBP1, TMBIM6, HNF1B, and Atg7/Beclin1 by modulating miR-128-3p, miR-128-1-5p, miR-1301-3p, miR-1207-3p, and miR-186, respectively (Fig. 8D–H) [23, 206–209]. This evidence concerns the gene PVT1 and central nervous system cancer.