[37, 38] found that PVT1 extensively affects CRC signaling pathways, including the TGFβ/Smad and Wnt/β-catenin signaling pathways, and promotes CRC cell metastasis by regulating MYC, which may lead to a poor prognosis by promoting the ability of CRC stem cells. The gene discussed is PVT1; the disease is colorectal carcinoma.