The top ten hub genes that have enhanced integration were explored to ensure the key metabolism-related genes involved in the CRC development, which comprises CPT2, ACOX1, EHHADH, HMGCS2, ENPP1, ECI2, ACSL6, SLC25A20, DGAT2, PCK1(Table 1). The gene discussed is DGAT2; the disease is colorectal carcinoma.