CPT2 and colorectal carcinoma: In order to investigate the biological role and the underlying mechanism of CPT2 in CRC, we maintained CRC cell lines as following: HCT116 and SW480 cells with relatively higher expression of CPT2 were transfected two different siRNAs (Fig. 6A, Supplementary Fig. 3A), while SW620 with lower expression of CPT2 were transfected with wild-type (WT) full-length CPT2 vectors (Fig. 6D) .