In S. fulviventer, several genes were downregulated upon infection related to immunoglobulin structure (HVM44), transcription factors (CREB1, CRY1), epithelial structure integrity (K2C8), formation and maintenance of tight junctions (OCLD), membrane trafficking regulation (CPNE3), targeted RNA degradation (MOV10), and tissue remodeling and homeostasis (MFGM). The gene discussed is CREB1; the disease is infection.