Univariate correlation analysis showed significant association of EZH2 expression with OS (P < 0.001), and the pathological type (HR = 5.96, 95% CI 0.55–64.67, P = 0.020) and EZH2 expression (HR = 2.35, 95% CI 1.62–3.42, P < 0.001) were significantly associated with OS in mesothelioma patients. This evidence concerns the gene EZH2 and mesothelioma.