As shown in Table 3, five pathways exhibited the strongest positive correlation with EZH2 expression: cell cycle pathway, DNA replication pathway, cell adhesion molecule pathway, primary immunodeficiency pathway, and taste conduction pathway; and five with the strongest negative correlation with EZH2 expression: glycolytic gluconeogenesis pathway, drug metabolism cytochrome P450 pathway, retinol metabolism pathway, fatty acid metabolism pathway, and ribosome pathway (Fig. 2). Here, EZH2 is linked to inborn error of immunity.