In this paper, the expression of EZH2 was statistically analyzed for the prognosis of mesothelioma depending on the clinical data from the TCGA database, and the correlation between EZH2 and immune infiltration in patients with mesothelioma was statistically analyzed, so as to further elaborate the potential mechanism of EZH2’s immune impact in this disease (tumor microenvironment) and seek the relevant impact mechanism. The gene discussed is EZH2; the disease is neoplasm.