Treatment with recombinant IL12 or IL13, at concentrations previously found in supernatant of cells exposed to serum from patients with delirium, decreases cell proliferation, neurogenesis and increase apoptosis, whereas co-treatment with the JAK inhibitors, baricitinib, ruxolitinib and tofacitinib, prevents these detrimental effects. This evidence concerns the gene IL13 and delirium.