We found that treatment of cells with serum samples from delirium patients decreased neurogenesis (DCX: group effect: p < 0.0001; time effect: p = 0.9, Fig. 2c and Supplementary Fig. 1k; Map2: group effect: p < 0.0001; time effect: p = 0.9, Fig. 2d and Supplementary Fig. 1l) and increased apoptosis (group effect: p < 0.0001; time effect: p = 0.9, Fig. 2e and Supplementary Fig. 1m), again with no differences between the two time points. This evidence concerns the gene MAP2 and delirium.