Of note, concentrations of the same cytokines (IL12 and IL13) in the original serum samples were much lower, and did not differ between delirium and non-delirium patients (IL12: 2.1 ± 1 pg/ml vs 2.05 ± 1 pg/ml, Supplementary Fig. 3f; IL13: 2.7 ± 0.7 pg/ml vs 2.8 ± 1 pg/ml, Supplementary Fig. 3g), indicating that these differences in the supernatant levels are due to new production of these cytokines by the cells. Here, IL13 is linked to delirium.