POU2F3 and small cell lung carcinoma: Surprisingly, the SCLC-non-NE cells in SCLC-A and SCLC-A/N and some SCLC-P tumors expressed neither POU2F3 nor YAP1, which might suggest new subtypes dominated by other TFs or the existence of transitional states (Supplementary Fig. S4c).31 To understand the spatial relationships of these transcriptional states, we performed multiplex immunofluorescence staining of these three TFs in all the samples.