MYC, which has been demonstrated in GEMMs to drive a NE-low “variant” subset of SCLC with NEUROD1 expression,10 exhibited a gradually decreased expression pattern from SCLC-non-NE to SCLC-A/N to SCLC-A cells (Supplementary Fig. S5b). Here, NEUROD1 is linked to small cell lung carcinoma.