In contrast, TAMs in the TME of SCLC expressed high levels of TCF4, IL2RA, PLA2G7, GAL3ST4, PLTP, CMKLR1, ADAMDEC1, and MMP12 (Fig. 2h), suggesting an immunosuppressive feature,28 and thus providing potential targets for SCLC immunotherapies. This evidence concerns the gene MMP12 and small cell lung carcinoma.