While AM_1 was composed exclusively of cells from NATs, and TAMs from the TME, AM_2 and AM_3 were composed of cells from both NATs and the TME, implying that they could be derived from precursors localized in lung tissues or potential migratory features of these two subtypes between tumor tissue and adjacent normal lung tissue.27 AM_2 exhibited higher expression levels of major histocompatibility complex (MHC) cluster II molecules (including HLA-DQA2, HLA-DRB6, and HLA-DRB5) than AM_1, implying enhanced antigen-presenting abilities of this cluster (Fig. 2h). Here, HLA-DRB5 is linked to neoplasm.