These data revealed that the TB susceptibility SNP rs1873613 in the dynamic loop anchor of LRRK2 enhancer could promote the LRRK2 enhancer activity, thereby upregulating the expression of the LRRK2. LRRK2 protein subsequently represses the clearance of M.tb by inhibiting phagosome maturation. The gene discussed is LRRK2; the disease is tuberculosis.