To confirm the effects of CRABP2 on the chemotherapy resistance of GC cells, we constructed stable knockdown AGS-OXA and HGC-27-OXA cell lines with lentivirus-carrying sh-RNA targeting CRABP2 (named sh-CRABP2) and stable overexpression AGS and HGC-27 cell lines (named oe-CRABP2). This evidence concerns the gene CRABP2 and gastric cancer.