However, PRMT5 supplementation obviously promoted IGFBP1 mRNA expression (31.56 vs. 91.18, P < 0.05) and secreted PRL levels (85.17 vs. 115.33 ng/mL, P < 0.001) (Fig. 7B, C), indicating that PRMT5 rescued the decidualization defect of endometrial stromal cells from endometriosis patients. This evidence concerns the gene PRL and endometriosis.