PAX8 and chronic kidney disease: Consistently, Pax8/SAV1ko mice showed an attenuated loss of kidney function at day 2 after AKI but developed a more severe CKD post-AKI, in comparison to both Pax8/WT mice that underwent nephrotoxic AKI and healthy Pax8/SAV1ko mice as well as an increased survival rate (Fig. 7l, m).