We concluded that the EA could increase intestinal motility by increasing ICC expression, thereby regulating the intestinal flora, enhancing the intestinal epithelial barrier function, and reducing the level of systemic inflammation, and ultimately regulating the IKKβ/NF‐κB‐JNK‐IRS‐1‐AKT signal pathway in the liver and muscles to improve glucose metabolism. This evidence concerns the gene AKT1 and intrahepatic cholangiocarcinoma.