Focusing on apoptosis caused by TKI and proteasome inhibitor treatment in Ph+ ALL cells, we also performed a two-step real time-qPCR and observed in both TOM-1 and BV-173 cells a significant (p<0.001,***) upregulation of proapoptotic TRAIL (tumor necrosis factor related apoptosis inducing ligand) in all dasatinib treated cells. Here, TNFSF10 is linked to acute lymphoblastic leukemia.