In the present study we identified 12 COPD hub gene clusters (SREK1, TMEM67, IRAK2, MECOM, ASB4, C1QTNF2, CDC42BPA, DPF3, DET1, CCDC74B, KHK, DDX3Y) from PPI network, which revealed their enrichment in cell regulation, immune process, transcription factors regulations and protein degradation pathways. Here, CCDC74B is linked to chronic obstructive pulmonary disease.