In conclusion, we identified, 12 blood based molecular biomarkers (SREK1, TMEM67, IRAK2, MECOM, ASB4, C1QTNF2, CDC42BPA, DPF3, DET1, CCDC74B, KHK, DDX3Y) for COPD diagnosis, by integrative gene expression and gene network approaches. The gene discussed is CCDC74B; the disease is chronic obstructive pulmonary disease.