In conclusion, we identified, 12 blood based molecular biomarkers (SREK1, TMEM67, IRAK2, MECOM, ASB4, C1QTNF2, CDC42BPA, DPF3, DET1, CCDC74B, KHK, DDX3Y) for COPD diagnosis, by integrative gene expression and gene network approaches. This evidence concerns the gene C1QTNF2 and chronic obstructive pulmonary disease.