ASB4 and chronic obstructive pulmonary disease: In conclusion, we identified, 12 blood based molecular biomarkers (SREK1, TMEM67, IRAK2, MECOM, ASB4, C1QTNF2, CDC42BPA, DPF3, DET1, CCDC74B, KHK, DDX3Y) for COPD diagnosis, by integrative gene expression and gene network approaches.