For the MECOM hub gene, the associated traits are pulmonary complications including COPD, asthma and lung function (Fig 4C and 4D No significant GWAS data linking the remaining 10 COPD-hub genes (SREK1, TMEM67, ASB4, C1QTNF2, CDC42BPA, DPF3, DET1, CCDC74B, KHK, and DDX3Y) with any kind of lung disease was found. The gene discussed is CCDC74B; the disease is chronic obstructive pulmonary disease.