While IFITM3 mRNA and protein were upregulated in sepsis patients, IFITM3 protein expression negatively correlated with systemic IFN-α levels, suggesting IFN levels increase early in sepsis, followed by transcriptional and translational changes in the megakaryocyte consistent with the kinetics of Ifitm3 expression changes in our murine studies. Here, IFNA1 is linked to Sepsis.