IFITM3 and Sepsis: While IFITM3 mRNA and protein were upregulated in sepsis patients, IFITM3 protein expression negatively correlated with systemic IFN-α levels, suggesting IFN levels increase early in sepsis, followed by transcriptional and translational changes in the megakaryocyte consistent with the kinetics of Ifitm3 expression changes in our murine studies.