HPSE and infection: In addition, we observed a significant increase in heparanase (HPSE) (3.1-fold increase) (31), galectin 3 binding protein (LGALS3BP) (3.0-fold increase) (32), and selenium binding protein 1 (SELENBP1) (3.0-fold increase) (33), which have been observed to be increased systemically during infection and inflammation, but have not been well studied in platelets.