When the lists of DEG obtained for each cell subset in blood and SF were compared (Supplemental Tables 4 and 6), 73 overlapping DEG in CD1c+ cDC were detected (Figure 2D), which were also enriched in TLR and IL-1–related pathways in CD1c+ cDC from both blood and SF in patients with RA (Figure 2E). Here, IL1B is linked to rheumatoid arthritis.