Interestingly, genes related to TLR stimulation, pyroptosis, the inflammasome, FcγR and FcεR signaling, activation of PRR, and signaling of inflammatory cytokines such as IL-1β, IL-6, IL-8, and N-Formyl-methionine-leucyl-phenylalanine (fMLP) were more significantly predicted to be affected in CD1c+ cDC compared with other myeloid subsets from PB of RA individuals (Figure 2B and Supplemental Table 5). The gene discussed is CXCL8; the disease is rheumatoid arthritis.