AIM2 and rheumatoid arthritis: In contrast, we did not observe any inflammasome related gene that passed our significance and log2 fold-change criteria in PB CD141+ cDC from patients with RA, although they showed less significant differential levels of alternative AIM2, PYCARD, or NOD2 and NLRP1 inflammasome sensors (52, 53) (Figure 7B and Supplemental Figure 8B).