In contrast, we did not observe any inflammasome related gene that passed our significance and log2 fold-change criteria in PB CD141+ cDC from patients with RA, although they showed less significant differential levels of alternative AIM2, PYCARD, or NOD2 and NLRP1 inflammasome sensors (52, 53) (Figure 7B and Supplemental Figure 8B). Here, PYCARD is linked to rheumatoid arthritis.