We observed that, in treated patients with RA experiencing improvement of clinical values over time, such as lower number of swollen joints and lower disease activity assessed by DAS28-ESR score (Figure 1A), proportions of circulating CD1c+ cDC were more significantly recovered (nominal P = 0.0067; FDR-corrected P = 0.0335) (Figure 1B). The gene discussed is CD1C; the disease is rheumatoid arthritis.