Interestingly, RNA-Seq data and quantitative PCR (qPCR) validation indicated that expression of proinflammatory cytokines such as IL-1β, IL-8, and MIP1α (CCL3) was downregulated in circulating CD1c+ cDC, CD141+ cDC, and Mo from patients with RA compared with HC (Figure 3, A and B, and Supplemental Figure 6A). This evidence concerns the gene CD1C and rheumatoid arthritis.