The mechanism by which AR activation suppresses MYC in prostate cancer was recently suggested to occur through AR-mediated sequestration of cofactors and decreased activity of distal super enhancers (SE) near PCAT1 that regulate the MYC promoter, as well as those of neighboring transcripts embedded in the topologically associated domain (TAD) on 8q24 (13). This evidence concerns the gene MYC and prostate cancer.