SCML1 and Azoospermia: There are limited data about SCML1, a novel gametogenesis and meiosis-associated protein, shown to be dispensable for mouse spermatogenesis but associated with azoospermia in human (Papanikos et al. 2017, Milunsky et al. 2020).Papanikos et al. (2017) have recently shown that SCML1 expression is restricted to the meiotic dense body, an enigmatic chromatin-free nuclear structure enriched with small-RNAs, and proposed to play a role in sex body formation (Papanikos et al. 2017).