The SCAT (Simvastatin/Enalapril Coronary Atherosclerosis Trial) and PREVEND IT (Prevention of Renal and Vascular Endstage Disease Intervention Trial) trials were placebo-controlled randomized clinical trials with a 2 × 2 factorial design to study the combined effects of ACE inhibitors and statins [43, 44]. This evidence concerns the gene ACE and coronary atherosclerosis.