SURF4 and Hypocholesterolemia: The profound hypocholesterolemia we observed in Surf4fl/fl Alb-Cre+ mice is in agreement with two other studies in which hepatic Surf4 was acutely inactivated using an AAV/Cas9 mouse system (Wang et al., 2021b) or a similar Surf4fl/fl and Alb-Cre model (Wang et al., 2021a).