Notably, a transmembrane ubiquitin ligase family member MARCH8 has been associated with lysosome degradation of both CD44 and CD81 in fibroblast cells (Bartee et al., 2010) and/or TNBC cells (Chen et al., 2021), suggesting CD44 and CD81 might follow similar fates of protein degradation or recycling in both cancer cells and other cells. Here, CD44 is linked to cancer.