Proteomic pathway and network analyses identified the top altered signaling pathways related to cell adhesion, integrin-mediated matrix adhesion, cell cycle, and cytoskeleton regulation and rearrangement, and a network linking to integrins and focal adhesion (Figure 3—figure supplement 2A–F), which may contribute to CD44-mediated functions in tumor metastasis (Liu et al., 2019; Liu et al., 2021). The gene discussed is CD44; the disease is neoplasm.