1,25(OH)2D3 binds via its vitamin D receptor and activates autophagy by inhibiting the mTOR/p70S6K signalling pathway, effectively decreasing the level of H2O2‐induced ROS in AF cells and increasing mitochondrial ATP content to improve mitochondrial function and inhibit AF cell apoptosis.108. The gene discussed is RPS6KB1; the disease is atrial fibrillation.