Among T2DM patients, the lifetime and 10 years of ASCVD risk showed significant negative correlation with serum 25(OH) D3 (r = −0.22, P=0.037); (r = −0.25, P=0.018) and HDLc (r = −0.37, P=0.0001); (r = −0.42, P=0.0001) respectively and significant positive correlation with body weight (r = 0.33, P=0.019); (r = 0.26, P=0.0001), T2DM duration (r = 0.24, P=0.019); (r = 0.42, P=0.0001), serum insulin (r = 0.32, P=0.002), (r = 0.35, P=0.001), HOMA-IR (r = 0.29, P=0.005), (r = 0.34, P=0.001), TC (r = 0.26, P=0.012), (r = 0.4, P=0.0001), and LDLc (r = 0.26, P=0.01), (r = 0.25, P=0.016). The gene discussed is INS; the disease is atherosclerosis.