Hereby, we identified that hsa_circ_0003176 (a circRNA derived from TBX5) was significantly downregulated in NSCLC tissues compared with match adjacent nontumorous tissues through analyzing the public lung cancer dataset in the GEO database and further to explored the biological function and underlying molecular mechanism of hsa_circ_0003176 in the development of NSCLC. Here, TBX5 is linked to non-small cell lung carcinoma.