The targets of the DEGs in GSE33857 were mainly enriched in PI3K/AKT and MAPK pathways, and the genes including SMAD2, FZD3, SMARCD2, PTEN, GAB1, TGFA, ARID1A, ARID2, MET, SOS2, TGFBR2, and NFE2L2 were related with the hepatocellular carcinoma related pathway (Figure 2(b)). This evidence concerns the gene SOS2 and hepatocellular carcinoma.