E2F1 and hepatocellular carcinoma: For GSE110217, the targets of the DEGs were also enriched in PI3K/AKT and MAPK pathways, and the genes including NRAS, CCND1, AKT3, PTEN, E2F1, AXIN2, SOS2, TGFBR1, and LRP6 were enriched in hepatocellular carcinoma related pathway (Figure 2(c)).