HSPA5 and neoplasm: In recent years, researchers found that high expression of HSPA5 is associated with antitumor cell activity, because factors such as insufficient blood supply and nutritional conditions may lead to the existence of stressful microenvironments such as hypoxia, hypoglycemia, and acidosis in tumor entities, which may lead to the overexpression of HSPA5 in tumors, which may be a defense mechanism of tumor cells under unfavorable survival conditions.