SOX4 and colorectal cancer: In order to explore whether the molecular pathway of PCGEM1/miR-129-5p/SOX4 exists in colorectal cancer or not, we subsequently analyze the effect of PCGEM1 on SOX4, which found that PCGEM1 silencing can significantly reduce endogenous SOX4 mRNA and protein expression in colorectal cancer cells (Figures 6(d) and 6(e)), which would be recovered by miR-129-5p silencing (Figure 6(f)).