The AOM/DSS-induced CAC mice were used to evaluate the CRC effect and the results showed the ZJSP (100 and 200 mg/kg) reduced the CAC polyps, promoted the recovery of damaged organs (heart, liver, spleen, lung, kidney, and pancreas), and raised the early CRC markers (COX-II, EMR1, and Ki67) in CAC mice. The gene discussed is MKI67; the disease is colorectal carcinoma.