KEGG analysis showed that GJB2 was significantly associated with a variety of diseases (Alzheimers disease, huntingtons disease, parkinsons disease, etc.), cell biological processes (cell cycle, DNA replication, p53 signaling pathway, TGF beta signaling pathway, JAK stat signaling pathway, etc.), and immune/inflammatory response (antigen processing and presentation, allograft rejection, primary immunodeficiency, cytokine cytokine receptor interaction, etc.)related pathways (Figure 7(b); Supplementary Table 11). This evidence concerns the gene TP53 and early-onset autosomal dominant Alzheimer disease.