The results of genome-wide methylated DNA immunoprecipitation sequencing (MeDIP-Seq) on lesions and healthy skins of psoriasis patients showed that differential methylated regions (DMR) covered almost all genomes, and the methylation levels of tissue inhibitor of metalloproteinase 2(TIMP2) and programmed cell death 5(PDCD5) were positively correlated with the score of psoriatic area and severity index (PASI) [20]. Here, PDCD5 is linked to psoriasis.