KEGG analysis demonstrated that hyper-MR-genes enriched only 1 pathway, which was Cell adhesion molecules (Figure 3(b); Supplementary Table 8); whereas hypo-MR-genes enriched a total of 35 KEGG pathways, including multiple diseases, viral infections, inflammatory responses, immune cells, and apoptosis, which contained Type I diabetes mellitus, Epstein-Barr virus infection, Allograft rejection, Th1 and Th2 cell differentiation, Apoptosis, etc. (Figure 3(d); Supplementary Table 9). The gene discussed is NR3C2; the disease is type 1 diabetes mellitus.