GJB2 and psoriasis: This evidence suggested that GJB2 may be involved in the development and progression of psoriasis by disrupting the body's immune system, mediating the cell cycle, and destroying the skin barrier, in addition to possibly inducing diseases related to the skeletal aspects of psoriasis, such as arthritic psoriasis, or being critical in the process of skeletal aberrations in patients with psoriasis treated with hormonal therapy.