Our prognostic analyses demonstrated that YTHDF1, IGFBP1, IGFBP2, IGFBP3, FTO, and ALKBH5 were unfavorable factors for STAD patients' OS while patients with higher levels of WTAP, RBM15, YTHDC2, TYHDF2, YTHDF3, HNRNPC, and LRPPRC were connected with better OS. The gene discussed is IGFBP3; the disease is gastric adenocarcinoma.