TNF and prostate carcinoma: It can be seen from the figure that KEGG enrichment results include Th17 cell differentiation, endocrine resistance, prostate cancer, estrogen signaling pathway, chemical carcinogenesis-receptor activation, coronavirus disease-COVID-19, and chemical carcinogenesis-reactive oxygen species, indicating key target Dot genes are significantly associated with tumor necrosis factor signaling pathway, chemical oncogenic-receptor activation, and endocrine resistance.