We also investigated the expression differences of IRGPI between categorical Clinicopathologic parameters; the expression of S100A16, RNASE7, LTB4R2, and INHA were different at different pathological stages; PLAU, CRABP1, IGKV1-6, and INHA were differentially expressed at different T stages; RBP2, RNASE7, LTB4R2, and GCGR expression associated with distant metastasis; and IL33, PDGFB, PNOC, and SHC3 correlated with lymph node metastasis. Here, IGKV1-6 is linked to metastatic malignant neoplasm in the lymph nodes.