SLCO1B3 and hepatocellular carcinoma: Wang et al. showed that OATP1B3 expression levels in low-grade heterogeneous nodules were the same as in the surrounding liver, 30% of highly heterogeneous nodules and 75% of early-stage hepatocellular carcinomas had reduced OATP1B3 expression, and all hypo fractionated hepatocellular carcinomas had reduced or absent OATP1B3 expression [11].