Of note, Varfrac in MREGvlf in the NT1 group was increased in the hypothalamus; the primary site of the hypocretin-producing cells, which in the human brain normally number some 100,000, but are presumably depopulated by a specific autoimmune reaction in narcolepsy type 1, thus causally leading to the disease2,69. The gene discussed is HCRT; the disease is narcolepsy-cataplexy syndrome.