HCRT and narcolepsy-cataplexy syndrome: Narcolepsy type 1 is hypothesized to arise from specific degeneration or dysfunction of the hypocretin-producing cells in the hypothalamus due to an autoimmune reaction that leads to decreased or absent hypocretin signaling in the ascending arousal network (AAN), hypothalamic tuberomammillary nucleus, and throughout the neocortex2,8.