We conclude that based on earlier findings and literature, our present findings of altered brain pulsations in narcolepsy type 1 most likely relate primarily to hypocretin deficiency and the consequent lack of hypocretin signaling on the downstream AAN and cortical regions, which in turn underlies possible autonomic alterations and altered sleep-wake patterns characteristic of narcolepsy type 1. This evidence concerns the gene HCRT and narcolepsy-cataplexy syndrome.