With the application of this method, the core prescriptions and the herbs involved for the three liver diseases were identified, which mainly intervened in the process of chronic hepatitis B, cirrhosis, and liver cancer through the intervention of signal transduction and immune system-related pathways and regulated the immune and cell growth processes, in which the PI3K-Akt was an important signaling pathway of it. The gene discussed is AKT1; the disease is liver disorder.