Our rescue assays demonstrated that the decreased apoptosis rate and caspase-3/7 expression in hypoxia-treated H9C2 cells under DAPA was rescued by Comp C. Thus, DAPA-induced autophagy activation can reduce cardiomyocyte apoptosis via the AMPK/mTOR pathway, thereby delaying HF progression. This evidence concerns the gene CASP3 and hydrops fetalis.