In contrast to being upregulated after TGFβ-1 (10 ng / mL) treatment, the ligand-receptor pair fibrillin 1 (fbn1) - integrin alpha-V (Itgav) was significantly downregulated after ALKi treatment: Fbn1 mutations are the main cause for Marfan Syndrome. The gene discussed is ITGAV; the disease is Marfan syndrome.