This finding is speculated to be related to IL28RA mRNA AS caused by hypoxia, which inhibits JAK-STAT and PI3K/AKT signaling pathways, promotes polarization of macrophages to M1, enhances inflammatory response and oxidative stress, significantly increases apoptosis and necrosis of myocardial cells, and increases the risk of myocardial fibrosis and heart rupture. The gene discussed is AKT1; the disease is Myocardial fibrosis.