MAPK1 and neoplasm: CASP8 was associated with the “ubiquitin-mediated proteolysis” pathway, while MAPK1 was associated with the “transforming growth factor β signaling pathway.” The MAPK3 gene was associated with four tumor-related cellular pathways: “cell cycle,” “DNA replication,” “pathways in tumors,” and “ubiquitin-mediated proteolysis.”