Thus, in this study, we also evaluated the peripheral inflammation with leukocyte number, neutrophil percentages, and HMGb1 level (a critical molecule in pathogenesis of sepsis [26]) in peripheral blood, and the neuroinflammation with microglial activation and inflammatory factors (IL-1,IL-6, and TNF-α) in the hippocampus. This evidence concerns the gene HMGB1 and Sepsis.