What is more, qRT-PCR and Western blot suggested that knockdown of circ_0000189 repressed the expression of ZEB2 in glioma cells, and co-transfection of miR-192-5p inhibitors reversed this change; overexpression of circ_0000189 promoted the expression of ZEB2 in glioma cells, while co-transfection of miR-192-5p mimics abrogated this effect (Figures 8(g) and 8(h)). The gene discussed is ZEB2; the disease is central nervous system cancer.