However, in contrast, low-dose QCT (10 mg/kg) also protects against diabetic kidney injury by inhibiting apoptosis [58] in hypercholesterolemic mice, it also alleviates acute kidney injury (AKI) by inhibiting the expression of activating transcription factor 3 (ATF3) and blocking ferroptosis in renal proximal tubular epithelial cells [59]. The gene discussed is ATF3; the disease is acute kidney injury.